Potential role of CC chemokine receptor 6 in prediction of late‐onset cytomegalovirus infection following solid organ transplant
Identifieur interne : 001957 ( Main/Exploration ); précédent : 001956; suivant : 001958Potential role of CC chemokine receptor 6 in prediction of late‐onset cytomegalovirus infection following solid organ transplant
Auteurs : Jose F. Camargo [Canada] ; Mariangela R. Resende [Canada, Brésil] ; Ricardo Zamel [Canada] ; William Klement [Canada] ; Alyajahan Bhimji [Canada] ; Sanja Huibner [Canada] ; Deepali Kumar [Canada] ; Atul Humar [Canada] ; Igor Jurisica [Canada] ; Shaf Keshavjee [Canada] ; Rupert Kaul [Canada] ; Shahid Husain [Canada]Source :
- Clinical Transplantation [ 0902-0063 ] ; 2015-06.
Abstract
CCR6 is a chemokine receptor involved in homing memory T cells, particularly Th17 cells, to sites of mucosal inflammation. Despite the critical role of memory T cells in long‐term protective immunity against cytomegalovirus (CMV), a virus that reactivates at multiple mucosal sites, the ability of CCR6 or other Th17 marker expression to predict CMV reactivation following transplantation is not clear. Using 11‐color flow cytometry, in this prospective single‐center pilot study, we measured the expression of CCR6 and other markers of T‐cell function in peripheral blood samples obtained from 21 SOT recipients at the time of discontinuation of anti‐CMV prophylaxis. CMV viremia was monitored on a monthly basis after discontinuation of prophylaxis. Eleven patients (52%) developed CMV viremia during the six‐month follow‐up period. Late‐onset CMV infection was preceded by an immune phenotype characterized by increased CCR6 expression on bulk CD4+ T cells and a reduced number of circulating CMV IE‐1‐specific Th1 (CD4+ IFN‐γ+) cells. Among the markers evaluated, CCR6 was the best single predictor of late‐onset CMV infection. Our results suggest that CCR6 expression at the time of discontinuation of antiviral prophylaxis might be a useful predictor of late‐onset CMV reactivation and provide the basis for future larger prospective studies.
Url:
DOI: 10.1111/ctr.12531
Affiliations:
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S" first="Shahid" last="Husain">Shahid Husain</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Transplant Infectious Diseases, Multi‐Organ Transplant Program, University Health Network, University of Toronto, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University Health Network, ON, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Transplantation</title><title level="j" type="alt">CLINICAL TRANSPLANTATION</title><idno type="ISSN">0902-0063</idno><idno type="eISSN">1399-0012</idno><imprint><biblScope unit="vol">29</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="492">492</biblScope><biblScope unit="page" to="498">498</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2015-06">2015-06</date></imprint><idno type="ISSN">0902-0063</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0902-0063</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">CCR6 is a chemokine receptor involved in homing memory T cells, particularly Th17 cells, to sites of mucosal inflammation. Despite the critical role of memory T cells in long‐term protective immunity against cytomegalovirus (CMV), a virus that reactivates at multiple mucosal sites, the ability of CCR6 or other Th17 marker expression to predict CMV reactivation following transplantation is not clear. Using 11‐color flow cytometry, in this prospective single‐center pilot study, we measured the expression of CCR6 and other markers of T‐cell function in peripheral blood samples obtained from 21 SOT recipients at the time of discontinuation of anti‐CMV prophylaxis. CMV viremia was monitored on a monthly basis after discontinuation of prophylaxis. Eleven patients (52%) developed CMV viremia during the six‐month follow‐up period. Late‐onset CMV infection was preceded by an immune phenotype characterized by increased CCR6 expression on bulk CD4+ T cells and a reduced number of circulating CMV IE‐1‐specific Th1 (CD4+ IFN‐γ+) cells. Among the markers evaluated, CCR6 was the best single predictor of late‐onset CMV infection. Our results suggest that CCR6 expression at the time of discontinuation of antiviral prophylaxis might be a useful predictor of late‐onset CMV reactivation and provide the basis for future larger prospective studies.</div></front></TEI><affiliations><list><country><li>Brésil</li><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Camargo, Jose F" sort="Camargo, Jose F" uniqKey="Camargo J" first="Jose F." last="Camargo">Jose F. Camargo</name></noRegion><name sortKey="Bhimji, Alyajahan" sort="Bhimji, Alyajahan" uniqKey="Bhimji A" first="Alyajahan" last="Bhimji">Alyajahan Bhimji</name><name sortKey="Bhimji, Alyajahan" sort="Bhimji, Alyajahan" uniqKey="Bhimji A" first="Alyajahan" last="Bhimji">Alyajahan Bhimji</name><name sortKey="Camargo, Jose F" sort="Camargo, Jose F" uniqKey="Camargo J" first="Jose F." last="Camargo">Jose F. Camargo</name><name sortKey="Huibner, Sanja" sort="Huibner, Sanja" uniqKey="Huibner S" first="Sanja" last="Huibner">Sanja Huibner</name><name sortKey="Humar, Atul" sort="Humar, Atul" uniqKey="Humar A" first="Atul" last="Humar">Atul Humar</name><name sortKey="Humar, Atul" sort="Humar, Atul" uniqKey="Humar A" first="Atul" last="Humar">Atul Humar</name><name sortKey="Husain, Shahid" sort="Husain, Shahid" uniqKey="Husain S" first="Shahid" last="Husain">Shahid Husain</name><name sortKey="Husain, Shahid" sort="Husain, Shahid" uniqKey="Husain S" first="Shahid" last="Husain">Shahid Husain</name><name sortKey="Husain, Shahid" sort="Husain, Shahid" uniqKey="Husain S" first="Shahid" last="Husain">Shahid Husain</name><name sortKey="Jurisica, Igor" sort="Jurisica, Igor" uniqKey="Jurisica I" first="Igor" last="Jurisica">Igor Jurisica</name><name sortKey="Kaul, Rupert" sort="Kaul, Rupert" uniqKey="Kaul R" first="Rupert" last="Kaul">Rupert Kaul</name><name sortKey="Kaul, Rupert" sort="Kaul, Rupert" uniqKey="Kaul R" first="Rupert" last="Kaul">Rupert Kaul</name><name sortKey="Keshavjee, Shaf" sort="Keshavjee, Shaf" uniqKey="Keshavjee S" first="Shaf" last="Keshavjee">Shaf Keshavjee</name><name sortKey="Klement, William" sort="Klement, William" uniqKey="Klement W" first="William" last="Klement">William Klement</name><name sortKey="Kumar, Deepali" sort="Kumar, Deepali" uniqKey="Kumar D" first="Deepali" last="Kumar">Deepali Kumar</name><name sortKey="Kumar, Deepali" sort="Kumar, Deepali" uniqKey="Kumar D" first="Deepali" last="Kumar">Deepali Kumar</name><name sortKey="Resende, Mariangela R" sort="Resende, Mariangela R" uniqKey="Resende M" first="Mariangela R." last="Resende">Mariangela R. Resende</name><name sortKey="Resende, Mariangela R" sort="Resende, Mariangela R" uniqKey="Resende M" first="Mariangela R." last="Resende">Mariangela R. Resende</name><name sortKey="Zamel, Ricardo" sort="Zamel, Ricardo" uniqKey="Zamel R" first="Ricardo" last="Zamel">Ricardo Zamel</name><name sortKey="Zamel, Ricardo" sort="Zamel, Ricardo" uniqKey="Zamel R" first="Ricardo" last="Zamel">Ricardo Zamel</name></country><country name="Brésil"><noRegion><name sortKey="Resende, Mariangela R" sort="Resende, Mariangela R" uniqKey="Resende M" first="Mariangela R." last="Resende">Mariangela R. Resende</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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